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In 1855 the first man-made plastic nitrocellulose branded Parkesine patented in 1862 was created by Alexander Parkes from cellulose treated with nitric acid and a solvent. Renal failure was due to upper urinary tract obstruction from fibrosis and fat necrosis in each case.


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Similar histological findings have been described in rabbit bladder exposed to sodium.

. In 1868 American inventor John Wesley Hyatt developed a plastic material he named Celluloid. Cellulose treated with sulfuric acid and potassium nitrate produces cellulose mononitrate. Two iodine-sensitive women in whom potassium bromide solution was used as a radiocontrast agent for retrograde pyelography developed similar clinical conditions culminating in renal failure.


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